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Bisphosphonates and denosumab are used extensively in the treatment of postmenopausal osteoporosis. Despite their proven efficacy in the reduction of vertebral and non-vertebral fractures, their optimal duration of use has not been determined. The occurrence of adverse effects, such as osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFF), has raised the issue of bisphosphonate or denosumab...
Klotho variants (KL-VS) have been associated with increased longevity and better cognitive function. It is unclear whether they modulate dementia risk.We recruited 527 men aged 71–87 years who were free of cognitive impairment. We used data linkage to track the onset of dementia over 10 years. KL-VS genotyping (rs9536314 T/G) followed standard procedures.The annual rate of dementia was 17.2‰ (95%CI=14...
Anti-Müllerian hormone (AMH), a quantitative marker of ovarian reserve, is used for both clinical and research purposes in the field of reproductive medicine. Numerous AMH assays have been developed. Among other factors, the lack of large-scale comparisons of the various assays hinders the universal interpretation of AMH levels. Moreover, little is known of the practical performance of highly sensitive...
Falls in the elderly represent a major health problem. The etiology of falls is usually multifactorial. Special attention should be paid on benzodiazepines (BZDs) since they are widely used by older adults.A literature search of the PUBMED and EMBASE databases from January 2007 to February 2017 was conducted using the MeSH terms “benzodiazepines”, “elderly” and “falls” or “accidental falls”. The systematic...
The association between early menarche and new onset of asthma warrants further investigation in those aged >30 years.Using data from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), we investigated whether early menarche was associated with new onset of asthma in women aged 18–60 years at baseline.Our analysis included 2492 women with information on age...
To explore women’s perspectives on what employers and managers should and should not do in relation to women going through the menopause.An online questionnaire was used to collect qualitative data in a cross-sectional study of working women. Three open-ended questions asked peri- and post-menopausal women, aged 45–65 years: (i) what they thought employers could do, or should do, to help menopausal...
To analyze the association between four biomarkers and overall survival in patients with breast cancer (BC).This cohort study had a sample of 2374 women over the age of 18, diagnosed and treated in a single reference center for BC in Brazil, during the year 2008–2009. The following pretreatment indices were analyzed: neutrophil–lymphocyte ratio (NLR), a derived neutrophil–lymphocyte ratio (dNLR),...
Obesity, insulin resistance and type 2 diabetes mellitus (T2DM) have been associated with endometrial cancer (EC). In this systematic review and meta-analysis we evaluated the effect of metformin on clinical outcomes in patients with EC and insulin resistance or T2DM.Four research databases were searched for original articles published in all languages up to 30 October 2016. Outcomes of interest were...
To identify causes of low age-adjusted bone mass at digital X-ray radiogrammetry (DXR) in individuals attending an osteoporosis screening program.In a descriptive observational cohort study, women aged 40–75 years who attended a general mammography screening program had their bone mass investigated with DXR and answered a questionnaire regarding several clinical risk factors for osteoporosis. Each...
Functional deterioration and reduced mobility in elderly patients with a hip fracture are associated with a loss of both muscle mass and function (sarcopenia). The aim of this study was to assess whether oral nutritional supplementation (ONS) improves muscle mass and nutritional markers (BMI, proteins) in elderly patients with hip fracture.Patients aged 65 years and over with hip fractures admitted...
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